Methadone use in humans A small dose of mephedrone (~0.2-1.5 g) per hour would be sufficient to cause severe headaches or temporary bodily discomfort, but the higher the dose, the less likely anxiety will occur. Analysis of recent blood tests using standard urine testing indicates that overdose is very likely after only a couple of consecutive trips.

Novelty effects are similar to other naphthoyls. A person with high exposure to methamphetamines experiences hallucinations of death and disasters such as suicide; some individuals report strong religious imagery associated with these experiences.